VP 720F-1

Parylene Coating of Tumble Stir Element

V&P Scientific also offers inexpensive stainless steel stir elements that are coated with parylene, for those applications facilitated by mixing (combinatorial chemistry and redox synthesis) where Fe molecules may interfere with the reaction, or the stirrers would be attacked by strong acids or bases.   The low cost of these parylene-coated stir elements allows them to be considered “disposable”.   Parylene (Di-Para-Xylylene) is deposited on the surface of the stirrer in a very uniform 0.05 mm thick layer, thus protecting the stirrers from strong acids and bases.  Parylene-coated stirrers can be autoclaved or sterilized in hot air ovens without harming the conformal coating.  Parylene can be heated to 200°C without harming the surface.

Parylene is also compatible with biological applications.  In fact, parylene is used to coat materials for implant procedures, as it is completely non-toxic to tissues.  See this page for a complete discussion of parylene’s barrier characteristics, properties, and methods of deposition.  See this page dedicated to parylene’ s resistance to organic solvents, acids, and bases. The Parylene Coated Tumble Stirrers can be dispensed with the same dispensers as their non-coated counterparts.

Many of the applications using parylene-coated stainless steel stir elements fall into the categories of parallel synthesis, combinatorial chemistry, and redox synthesis that are done by pharmaceutical companies, and most are never published in order to keep their data and methods private.  One of our customers at a large pharmaceutical company sent us this compliment in an email –

Testimonial

“Patty and Patrick-

There is a long, official process (read: involves the Legal department) for allowing endorsements of products with _______’s and/or my name. However, I would be happy to share my personal feedback with you.  If you would like to refer to this to anyone as unofficial information (ie, “It came from someone in Process R&D in major Pharma.”), that would be great. At the least, you’ll see exactly why I love these stirrers.

Feedback for the Tumble Stirrers is this: enabling technology. I am now enabled to create reaction blocks and customize them to robotic systems with great ease.  Why? The narrow deck height of the Tumble stirrers (even my larger strength units) combined with the flexibility of alignment for the stirrers to the reaction vessels means I can use them almost anywhere.

The fact that I can use the same stirrer deck with any type/size of reactor simply by changing a mounting plate atop the stirrer deck gives me the kind of flexibility I require for parallel synthetic development of processes. That flexibility enables access to a wider range of projects (smaller scale) and a wider range of reaction conditions. I get more reactions per gram of starting material for evaluation of more diverse conditions, and I generate results faster because I run more of the experiments in parallel using the same amount of starting material. In one word, Tumble Stirring is enabling.

Oh, and the quality of agitation is fantastic for liquid-liquid mixes, slurries, or even oil suspensions.

Thanks again for this terrific product.

D____.”